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Application and Manufacturing Method of Stent Material in Vascular Regeneration and Prevention of Vascular Restenosis

Received: 29 March 2021     Accepted: 14 April 2021     Published: 23 April 2021
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Abstract

With the development of biological tissue engineering, vascular stent materials have been greatly improved. Synthetic polyester polymers and bio-derived materials with excellent biocompatibility, biodegradability and mechanical strength have greatly improved. These are ideal tissue vascular scaffold materials. Vascular stents mainly play two roles in the body: vascular regeneration and prevention of vascular restenosis. In terms of vascular regeneration, the repair of common bone defects and the pulp regeneration require revascularization. This type of stent has production-promoting ability of adopting the multi-level microtubule structure. Different aperture induces different vascular behavior of making the adhered macrophages deforming correspondingly, promoting the infiltration of endothelial cells into the extracellular matrix and accelerating the formation of new blood vessels. In the treatment of atherosclerosis, stents can not only support blood vessels, but also prevent blood vessel from restenosis and keep blood vessels opening for a long time. To this aim, stents generally carry and controllable release of drugs of inhibiting the proliferation of smooth muscle cells. Such stents are called drug-eluting stents. Usual drugs are rapamycin and paclitaxel. This review intends to mix the nano-scale anticancer drug nanoenzymes with polymers on the surface of the stent and exert the sustained drug releasing function of the drug-eluting stent. This type of drug-eluting stent can not only prevent blood vessel restenosis, but also treat cancer by attacking tumor cells.

Published in International Journal of Materials Science and Applications (Volume 10, Issue 2)
DOI 10.11648/j.ijmsa.20211002.13
Page(s) 35-45
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Angiogenesis, Vascular Restenosis, Multi-level Microtubule Structure, Drug-eluting Stent, Nanoenzyme

References
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Cite This Article
  • APA Style

    Wenqi Fan. (2021). Application and Manufacturing Method of Stent Material in Vascular Regeneration and Prevention of Vascular Restenosis. International Journal of Materials Science and Applications, 10(2), 35-45. https://doi.org/10.11648/j.ijmsa.20211002.13

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    ACS Style

    Wenqi Fan. Application and Manufacturing Method of Stent Material in Vascular Regeneration and Prevention of Vascular Restenosis. Int. J. Mater. Sci. Appl. 2021, 10(2), 35-45. doi: 10.11648/j.ijmsa.20211002.13

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    AMA Style

    Wenqi Fan. Application and Manufacturing Method of Stent Material in Vascular Regeneration and Prevention of Vascular Restenosis. Int J Mater Sci Appl. 2021;10(2):35-45. doi: 10.11648/j.ijmsa.20211002.13

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  • @article{10.11648/j.ijmsa.20211002.13,
      author = {Wenqi Fan},
      title = {Application and Manufacturing Method of Stent Material in Vascular Regeneration and Prevention of Vascular Restenosis},
      journal = {International Journal of Materials Science and Applications},
      volume = {10},
      number = {2},
      pages = {35-45},
      doi = {10.11648/j.ijmsa.20211002.13},
      url = {https://doi.org/10.11648/j.ijmsa.20211002.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmsa.20211002.13},
      abstract = {With the development of biological tissue engineering, vascular stent materials have been greatly improved. Synthetic polyester polymers and bio-derived materials with excellent biocompatibility, biodegradability and mechanical strength have greatly improved. These are ideal tissue vascular scaffold materials. Vascular stents mainly play two roles in the body: vascular regeneration and prevention of vascular restenosis. In terms of vascular regeneration, the repair of common bone defects and the pulp regeneration require revascularization. This type of stent has production-promoting ability of adopting the multi-level microtubule structure. Different aperture induces different vascular behavior of making the adhered macrophages deforming correspondingly, promoting the infiltration of endothelial cells into the extracellular matrix and accelerating the formation of new blood vessels. In the treatment of atherosclerosis, stents can not only support blood vessels, but also prevent blood vessel from restenosis and keep blood vessels opening for a long time. To this aim, stents generally carry and controllable release of drugs of inhibiting the proliferation of smooth muscle cells. Such stents are called drug-eluting stents. Usual drugs are rapamycin and paclitaxel. This review intends to mix the nano-scale anticancer drug nanoenzymes with polymers on the surface of the stent and exert the sustained drug releasing function of the drug-eluting stent. This type of drug-eluting stent can not only prevent blood vessel restenosis, but also treat cancer by attacking tumor cells.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Application and Manufacturing Method of Stent Material in Vascular Regeneration and Prevention of Vascular Restenosis
    AU  - Wenqi Fan
    Y1  - 2021/04/23
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijmsa.20211002.13
    DO  - 10.11648/j.ijmsa.20211002.13
    T2  - International Journal of Materials Science and Applications
    JF  - International Journal of Materials Science and Applications
    JO  - International Journal of Materials Science and Applications
    SP  - 35
    EP  - 45
    PB  - Science Publishing Group
    SN  - 2327-2643
    UR  - https://doi.org/10.11648/j.ijmsa.20211002.13
    AB  - With the development of biological tissue engineering, vascular stent materials have been greatly improved. Synthetic polyester polymers and bio-derived materials with excellent biocompatibility, biodegradability and mechanical strength have greatly improved. These are ideal tissue vascular scaffold materials. Vascular stents mainly play two roles in the body: vascular regeneration and prevention of vascular restenosis. In terms of vascular regeneration, the repair of common bone defects and the pulp regeneration require revascularization. This type of stent has production-promoting ability of adopting the multi-level microtubule structure. Different aperture induces different vascular behavior of making the adhered macrophages deforming correspondingly, promoting the infiltration of endothelial cells into the extracellular matrix and accelerating the formation of new blood vessels. In the treatment of atherosclerosis, stents can not only support blood vessels, but also prevent blood vessel from restenosis and keep blood vessels opening for a long time. To this aim, stents generally carry and controllable release of drugs of inhibiting the proliferation of smooth muscle cells. Such stents are called drug-eluting stents. Usual drugs are rapamycin and paclitaxel. This review intends to mix the nano-scale anticancer drug nanoenzymes with polymers on the surface of the stent and exert the sustained drug releasing function of the drug-eluting stent. This type of drug-eluting stent can not only prevent blood vessel restenosis, but also treat cancer by attacking tumor cells.
    VL  - 10
    IS  - 2
    ER  - 

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  • Material Science and Engineering, Harbin Institute of Technology, Harbin, China

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